29-4 CAS Suzhou Institute of Biomedical Engineering and Technology develops antibiotic resistance test based on Raman spectroscopy
In this test, metabolically active bacteria in the presence of D2O will take in deuterium from D2O via NADPH and add D into biomolecules to form carbon-deuterium (C-D) bonds. The cells containing C-D bonds show a distinguishable Raman band shifted from C-H vibration, and the band can serve as a distinct biomarker for the metabolic activity […]