Month: September 2023

CAS TIB proposes synthesis of vitamin B6 using engineered E. coli cells

https://www.cas.cn/syky/202309/t20230908_4969423.shtml https://www.nature.com/articles/s41467-023-40928-0 Vitamin B6 is one of the essential nutritional elements for living organisms, including six forms, taking pyridoxal phosphate PLP as a coenzyme form to participate in amino acid and sugar metabolism, heme and neurotransmitter synthesis and other processes. Pyridoxine PN is the main commercial form. Some microorganisms and plants can synthesize vitamin B6 de novo, and animals and humans rely on external sources to supplement vitamin B6. At present, vitamin B6 mainly relies on chemical synthesis. Biomanufacturing has the advantages of mild reaction conditions, less potential safety hazards, and environmental friendliness. Recently, the protein synthesis cell factory and microbial metabolism research team led by Zhang Dawei, a researcher at the CAS Tianjin Institute of Industrial Biotechnology has made new progress in the microbial synthesis of vitamin B6. The study used Escherichia coli as the chassis cell to reconstruct the de novo vitamin B6 synthesis pathway and redirect the metabolic flow to uncouple cell growth and PN production. Furthermore, the study used methods such as protein rational design and natural screening to carry out heterologous screening and rational design modification of the initial enzymes Epd and Dxs of the synthetic pathway and the rate-limiting enzymes PdxA and PdxJ, which effectively solved the problem of low catalytic efficiency of synthetases in the reaction process, increased metabolic flux and promoted the rapid turnover of PdxB through overexpression of SerC. In order to reduce effects of the toxic intermediate 4HTP, the synthesis pathway was divided into upstream and downstream push-pull modules. The upstream module and the downstream module were effectively assembled and optimized through modular iterative optimization technology. After 48-hours in a 5L fermentation tank, the yield of vitamin B6 exceeded the gram level.

China Atomic Energy Authority and IAEA hold joint workshop on small modular reactors in Hainan

https://english.news.cn/20230905/fd4f5009d1484879b355d23a7520e3b3/c.html An interregional workshop on the technology development and application of small modular nuclear reactors (SMRs) was jointly hosted by the International Atomic Energy Agency (IAEA) and the China Atomic Energy Authority (CAEA), attended by over 200 government officials, experts, and scholars from over 50 countries and regions. SMRs could serve in multiple areas, like powering small and medium-sized electricity grids, urban heating, industrial steam supply, seawater desalination, and isotope production.

CAS Guangzhou Institutes of Biomedicine and Health grows humanised kidneys in pig embryos

https://english.news.cn/20230908/3eaae910c860487c9fb646aae7b1ce86/c.html A Chinese team has grown early kidneys from human stem cells inside pig embryos, according to a study published in Cell Stem Cell. The scientists from CAS Guangzhou Institutes of Biomedicine and Health used a gene-editing tool to engineer certain genes in human induced pluripotent stem cells (IPSCs) to strengthen their capability to gain a foothold and form kidneys in pig embryos that are genetically modified to lack the ability to grow a kidney. The researchers finally harvested five embryos with organized human-pig chimeric middle-stage kidney structures within 28 days and those human donor cells could differentiate into functional cells. The proportion of human cells in the chimeric kidneys reached up to 70 percent, and the proportion of human cell contribution in the formation of mesonephric tubules reached a maximum of 58 percent. The gestation was terminated within 3 to 4 weeks in accordance with current ethical rules.

Big Data Center publishes satellite data on BRI urban nighttime light emissions

https://english.news.cn/20230906/80d41d7d0ced4bdea2f6a0bdd2fed8fe/c.html The International Research Center of Big Data for Sustainable Development Goals (CBAS) has released the world’s first atlas of urban nighttime light remote-sensing data, providing support for the research on urban sustainable development. The atlas contains 10-meter resolution nighttime light data on 147 cities in 105 countries around the world. The data were captured by the satellite SDGSAT-1, which was launched into space on Nov. 5, 2021 and is the world’s first space science satellite dedicated to serving the U.N. 2030 Agenda for Sustainable Development. The satellite is designed to provide space observation data for the monitoring, evaluation and study of interactions between humans, nature and sustainable development, according to its developer, the Chinese Academy of Sciences. The SDG Center signed a cooperation agreement with the Earth Observation Organization. The two parties will continue to carry out cross-field cooperation in data sharing, talent exchanges, capacity building and other aspects, and jointly explore ways to accelerate the progress of the second half of the United Nations’ 2030 Agenda for Sustainable Development. method.

Coastal ecosystems are important contributors to China’s CO2 storage

https://www.cas.cn/cm/202309/t20230906_4968761.shtml Coastal blue carbon ecosystems, including mangroves, salt marshes, and seagrass beds, have efficient carbon dioxide sequestration capabilities, so protecting and restoring these ecosystems has become an important “nature-based solution.” China’s coastal blue carbon ecosystem has a total area of 1.44 million hectares and a carbon storage of up to 118 Tg. Among them, the total carbon storage of mangroves is about 6.9 Tg; the total carbon storage of seagrass bed ecosystem is about 1.4 Tg, which is much lower than the total carbon storage of salt marsh wetlands, which is about 25 Tg. In addition, my country has a vast area of ​​coastal beaches that are not covered by vegetation, and the total carbon storage is as high as 27~85 Tg. In addition to carbon storage, the carbon burial capacity of these coastal blue carbon ecosystems also deserves attention. The total carbon burial amount of China’s mangroves is about 0.05 Tg/yr, the total carbon burial amount of seagrass beds is 0.01~0.02 Tg/yr, and the total carbon burial amount of salt marsh wetlands is 0.50 Tg/yr; the total carbon burial amount of China’s coastal beaches without vegetation coverage is 0.28~1.5 Tg/yr. Coastal blue carbon systems usually have very low methane emissions, but under certain special circumstances, such as low salinity, they can also emit a certain amount of methane. The total methane emissions from China’s mangroves are 0.01 Tg/yr, Currently, human activities have led to the loss of large amounts of coastal blue carbon ecosystems. In the 20th century, global coastal wetlands decreased by 25% to 50% due to human activities. Since 1950, the total area of mangrove forests in China has been reduced by half. In 2021, China planned to restore mangroves to 48,650 hectares in the next 10 years, which is expected to further absorb 0.1 Tg of carbon per year.

Model suggests that urban areas account for <4% of global land but >70% of global CO2 emissions

https://english.cas.cn/newsroom/research_news/life/202309/t20230907_336139.shtml In a study published in Science of the Total Environment, researchers from the Xishuangbanna Tropical Botanical Garden (XTBG) of the Chinese Academy of Sciences and Hohai University proposed a new method to calculate urban socioeconomic development indexes using a variety of data sources.  Based on the lighting index, business point of interest (POI) data and output value, the researchers obtained an urban socioeconomic development index for the Yangtze River Delta YRD. Based on this index, they classified YRD urban units into core cities, transitional cities, and peripheral cities based on this index. Using extended Kaya index decomposition models, they evaluated the effects of regional industrial growth, consumer markets, and spatial expansion on urban CE. They then examined differences in the drivers of CE between and within these categories of cities. They found that the key to reducing emissions in core cities lied in residents’ market consumption, while peripheral cities had greater potential for CE reduction in terms of industrial upgrading and spatial layout. For the YRD city cluster as a whole, resident market consumption was the most important driver of CE in the YRD megacity cluster, followed by spatial expansion. Industrial transformation and upgrading reduced CEs. Various factors influenced intra-group differences in CE intensity, including industrial structure, population density, per capita living effect, spatial expansion effect, population size effect, urbanization effect, and consumption inhibition effect, etc. “Residents’ consumption was the most important factor of CE in most cities. The authors conclude that promotion of forward-looking green low-carbon consumption is required to minimize the impact of human activities on the environment.

2023/08 China leads use of geothermal energy with 38% of global

China’s direct geothermal energy use will reach 40.6 gigawatts (GW) by the end of 2020, accounting for 38% of the world’s total, making it the largest in the world for several consecutive years. China’s geothermal energy heating and cooling area is 1.39 billion square meters, with an average annual growth rate of 23% over the past five years. Why is geothermal getting so much attention? According to industry insiders, it has to do with its wide distribution, large reserves, stability and reliability, and remarkable carbon emission reduction benefits. The distribution of energy resources in China usually has regional bias. For example, the northwest is rich in coal, wind, and solar energy resources, while the south is rich in water resources. In contrast, geothermal energy is widely distributed and the process of using it emits almost no carbon. The goal of “double carbon” (peak CO2 emissions and carbon neutrality) has brought clean geothermal energy into the spotlight. Two examples were provided: At the China Petroleum & Chemical Industry Group Green Energy Corporation Talent Jiayuan Heat Exchange Station in Xiong County, Xiong’an New District, Hebei Province, the heat exchange station is located underground. It does not have a large site area, but it guarantees a winter heating supply for the more than 3,000 households in the complex. At this heat exchange plant, geothermal water is pumped up by submersible pumps, sand is removed by desander, and heat is exchanged in plate heat exchangers. In other words, the heat from the high-temperature underground water is extracted and used as a heat source for winter heating. The thermal energy obtained from the geothermal water is sent to each household through pipes. At China Petrochemical Green Energy Geothermal Energy Development Corporation, shallow geothermal energy is used instead of air conditioning for cooling. There are about 280 shallow pit holes about 120 meters deep under the green areas and roads in the complex, and the underground thermal energy is transported by pipes to exchange cold and heat between water and underground rock bodies through the action of heat pump units. In winter, the heat from the rock is extracted and used to heat the rooms. In the winter, the heat is extracted from the rock body and used to heat the rooms, and the underground rock body serves as the heat source in this process. In summer, the indoor heat is extracted and released into the rock to produce cold water at a temperature of about 11°C. A circulation pump then sends the water to a fan for circulation. Geothermal energy can be used in different stages based on different temperatures. Taking Yadu County, Dali City, Yunnan Province, as an example, where medium- and high-temperature geothermal energy is abundant, geothermal energy below 45°C can be used to develop the healthcare industry, such as hot springs and bathing; between 45 and 60°C can be used for heating; and around 60 to 90°C, energy after heating use can be used for greenhouse cultivation. On the other hand, geothermal energy above 90°C can be used for clean power generation. The higher the temperature, the more effective and economical the power generation.   Photo shows the heat exchange station located at the Hebei Xiong’an New District Innovation Center Intermediate Test Base.

China’s T1000 carbon fibres achieve mass production

http://j.people.com.cn/n3/2023/0823/c95952-20062224.html A technical appraisal meeting presided over by the China Petroleum and Chemical Industry Federation was held on August 20, and China-made ultra-high-strength ZA60XC (T1000) PAN carbon fiber 1000 ton-class industrial production technology passed the technical appraisal of the expert committee. The expert committee stated, “This achievement has reached the world’s top level. Among them, the precursor structure design and representation analysis technology lead the world, and the appraisal was unanimously passed. Carbon fiber is known as the “gold of industry” and the “king of new materials.” With its high strength, high Young’s modulus ratio, corrosion resistance, fatigue resistance, and high temperature resistance, carbon fiber is an indispensable strategic material in such fields as aerospace, national defense and military industry, transportation, new energy, and marine engineering. For a long time, the most core advanced technology of carbon fiber, especially the technology for large-scale mass production of ultra-high-strength carbon fiber, has been monopolized by developed countries. According to Changsheng Technology officials, the demand for carbon fiber and its composite materials is rapidly increasing with China’s economic and social development. China’s carbon fiber production has gone from near zero to accounting for one-third of global production by 2022. Most production capacity, however, remained at the T300 and T700 levels. High-end T800 products lacked quality stability, and ultra-high-performance carbon fiber products above T1000 had only 100-ton-level technological achievements, and large-scale and stable production at the 1000-ton level could not be realized. After more than two years of research and development, in which Changsheng Technology was in charge and Shenzhen University cooperated, a production line with an annual capacity of 1,700 tons was able to stably produce T1000 products. According to inspections, its performance has reached the level of comparable products in the world, with a product quality acceptance rate of more than 95.6%.

Major TCM hub pushes for standardized herb cultivation

https://english.news.cn/20230825/67d2999fe9504c9791acc245abea4add/c.html LANZHOU, Aug. 25 (Xinhua) — Under the scorching sun in Dongjiabao Village in the heartland of Gansu Province, northwest China, Yan Baiping, 38, is busy weeding his traditional Chinese medicine (TCM) crops. Yan’s TCM herbs are thriving thanks to the region’s growing emphasis on standardized cultivation methods, which promotes eco-friendly cultivation and innovative pest control techniques, thereby reducing the usage of fertilizers and pesticides. China has been promoting the standardized green cultivation of TCM herbs to meet market demand for high-quality, high-yield herbs that adhere to these standards. A decade ago, due to poor cultivation practices, Yan struggled with lower herb quality and reputation, as well as price pressure from buyers. Over the last 10 years, he has embraced green standards, joining a local demonstration base for TCM herb cultivation. Under the Good Manufacturing Practice standards established by leading local pharmaceutical companies and expert guidance, his yields increased. The government also provides organic fertilizers as subsidies annually. Last year, various favorable policies saw Yan earn over 30,000 yuan (about 4172.5 U.S. dollars) from 0.33 hectares of TCM herbs. This year, he expanded the field to nearly 2 hectares, anticipating an income increase of over 30,000 yuan. Gansu is a major base for the production and supply of TCM raw materials. In 2022, 1.47 million tonnes of TCM herbs were produced in Gansu, ranking among the top nationwide, and 55 percent of them were cultivated using standardized methods, local statistics showed. Longxi County in Gansu benefits from a unique natural climate that is exceptionally suited for the growth of various TCM herbs. To maintain quality, Longxi allocated over 30 million yuan annually for standardized cultivation. At present, 23,300 hectares of the county’s 33,300 hectares of total TCM herb planting areas have adopted standardized green cultivation, said Wang Wei, director of the county’s office for TCM industry development. On Thursday, the fourth China (Gansu) Traditional Chinese Medicine Industry Expo kicked off in Longxi. Many attendees highlighted that the continuous promotion of standardized cultivation will provide a solid foundation for the inheritance and innovation of TCM in China. Yu Yanhong, head of China’s National Administration of Traditional Chinese Medicine, said during the expo that authorities are rapidly formulating documents to promote the high-quality development of the TCM industry, while enhancing technological research and development throughout the entire industry chain. “To enhance the standardization of TCM herb cultivation, China is focusing on improving the quality of herbs from the source and advocating for a comprehensive quality tracing system across the entire chain, thus, enhancing the core competitiveness of the TCM industry,” Yu said.

UNICEF partners with China to pilot climate-resilient WASH technologies in Cambodia

http://en.people.cn/n3/2023/0830/c90000-20065241.html PHNOM PENH, Aug. 29 (Xinhua) — Delegates from China and the United Nations Children’s Fund (UNICEF) on Tuesday started a three-day field visit to Cambodia to conduct a feasibility study for piloting climate-resilient water and sanitation (WASH) technologies and solutions in the kingdom, said a UNICEF’s press statement. The Cambodia-China Climate-Resilient WASH Cooperation Project is part of the South-South cooperation program between the two countries and UNICEF, the statement said. “The feasibility study mission to Cambodia aims to leverage Chinese expertise on solar-powered water supplies, water purification and fecal sludge treatment in urban and rural areas to help identify gaps in technology and infrastructure,” the statement said. UNICEF Representative to Cambodia Will Parks said the Children’s Climate Risk Index ranks Cambodia in the top third of nations facing high risks to the impacts of climate change, and that children are highly exposed to water scarcity, riverine flooding, and vector-borne diseases, among others. “We are grateful to the People’s Republic of China and UNICEF China for their support in implementing innovative, climate-resilient responses that build sustainable environments for the most vulnerable communities,” he said. In Cambodia, one in four people in rural areas still lack access to improved water resources and sanitation, presenting risks to public health, hindering development and resulting in water resource contamination risks, according to the statement. “UNICEF China is working closely with our partners to promote international cooperation on children’s rights and the Sustainable Development Goals,” Acting UNICEF Representative to China Nenad Radonjic said. “This collaboration between Cambodia and China is a good example of how we can act as a facilitator for knowledge exchange and technical cooperation in the sector of WASH, climate and the environment, to help address common and critical challenges facing children globally,” he added.

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