Month: September 2012

Team at CAS Qingdao Institute of Bioenergy and Bioprocess Technology develops ethanol producing engineered Synechocystis sp. strain

Ethanol-producing efficiency was 5.50 g/L, 212 mg/L/day, and the strain was constructed by genetically introducing pyruvate decarboxylase from Zymomonas mobilis and overexpressing endogenous alcohol dehydrogenase through homologous recombination at two different sites of the chromosome, and disrupting the biosynthetic pathway of poly-b-hydroxybutyrate Zhengxu Gao et al., Energy Environ. Sci., 2012, DOI: 10.1039/C2EE22675H

CAS Chengdu Institute of Biology develops asymetric reduction process for baclofen intermediate based on a new enoate reductase from Achromobacter

A group around Prof. Zhongliu WU identified Achromobacter sp. JA81 which can reduce (Z)-3-cyano-3-phenyl-propenoic acid to (R)-3-cyano-3-phenyl- propanoic acid with 70% yield and good enantioselectivity (90% ee). By sequencing and annotating the genome and cloning candidate genes into E. coli, the enoate reductase responsible for this reaction could be identified. Appl. Microbiol. Biotechnol., Sept. 27, 2012

CAS Tianjin Institute of Industrial Biotechnology achieves 81 % enhanced yield of succinic acid from metabolically engineered strain of E. coli

Two glucose transport proteins and two glucokinases (Glk) from E. coli and Zymomonas mobilis were recruited in PTS− strains of E. coli, leading to 2.13 g/L•h), 81 % higher than the wild-type E. coli. J. TANG et al., Applied Microbiology and Biotechnology 2012, DOI: 10.1007/s00253-012-4344-1

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