Month: January 2014

Team at CAS Tianjin Institute of Industrial Biotechnology develops platform for D-amino acid synthesis

Based on a gene mining approach using Symbiobacterium thermophilum, the group around Professor Duming ZHU obtained first a meso-diaminopimelate dehydrogenase of which a crystal structure was obtained. By protein engineering, the substrate binding pocket was changed to allow the conversion of a wide range of L- to the D-amino acids via intermediary keto-acids and reductive […]

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