Trans-aconitic acid from Aspergillus terreus – a new biopesticide and bio-based plasticizer

Trans-aconitic acid TAA (CAS RN 4023-65-8) is an unsaturated tricarboxylic acid that occurs in various plants. Although it exhibits broad application potential in agriculture, food, biomaterials, and green chemistry, its practical use remains limited. This is primarily because the traditional production processes of plant extraction (from sugar cane)and chemical synthesis (complex and inefficient) cannot achieve large-scale production at a low cost.

Researchers around LU Xuefeng, director of the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) under the Chinese Academy of Sciences, have now established a cell factory for the production of TAA based on a genome-edited industrial strain of Aspergillus terreus. Several rounds of metabolic engineering resulted in strains which produced 57 g/L TAA in shake flask cultures. Scale-up to tank fermentations up to 120 kL – in cooperation with Shandong Lukang Pharmaceutical Co., Ltd.– then led to yields of 88 g/L after 100 hours. A simple recovery procedure combining membrane concentration and crystallization provided TAA crystals with a purity of 98.4%. Given its superior nematicidal properties, QIBEBT and Lukang Pharmaceutical are now in the process of registering TAA as a new nematicide biopesticide.

The QIBEBT team has further found that TAA esters (trans-Aconitates) can be used as plasticizers and could replace the ambiguous phthalates widely used in plastic products. Haier Blood Technology Co., a Qingdao-based company, plans to use TAA esters as plasticizers in its PVC-based blood bags and other products.

TAA ester’s wide temperature stability, from -46°C to 120°C, might also find applications in automotive cable materials as they exhibit excellent resistance to high-temperature volatilization and low-temperature brittle cracking.

In summary, biomanufacturing based on smart cells of A. terreus has provided a new material, TAA and TAA esters, which offer exciting application potentials as a biopesticide and a non-toxic bioplasticizer.

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Nature 2025 science city ranking: six of top 10 in China, Qingdao is 31 between Munich and Berlin

https://www.nature.com/nature-index/supplements/nature-index-2025-science-cities/tables/overall

https://en.people.cn/n3/2025/1118/c90000-20391615.html

The newly released “Nature Index 2025 Science Cities” supplement shows that the number of Chinese cities in the global top ten rose from five in 2023 to six in 2024, marking the first time China holds a majority in the rankings.

The supplement draws on the Nature Index database, which tracks research articles published from 2015 to 2024. Its analysis uses “Share”, a fractional count reflecting institutional contribution to publications, as the primary metric, with time-series data adjusted to 2024 levels. Each city’s Share is calculated by summing the contributions of all affiliated institutions located within that city.

According to the Nature Index, the world’s leading science cities overall are: Beijing, Shanghai, New York metropolitan area (U.S.), Boston metropolitan area (U.S.), Nanjing (China), Guangzhou (China), San Francisco Bay Area (U.S.), Wuhan (China), Baltimore-Washington metropolitan area (U.S.), and Hangzhou (China).

Further analysis shows that Chinese cities hold a strong advantage in chemistry, physical sciences, and earth and environmental sciences, leading the global rankings in all three fields. Notably, Chinese cities claimed all of the top ten positions in chemistry for the first time. In the other two subject areas, they secured six of the top ten spots, with Beijing ranking first worldwide across all three domains.

European cities in the ranking start at 19 (London), followed by Zurich (28), Cambridge (29), Munich (30) and Berlin (32), following Qingdao at position 31.

Green Carbon Journal: call for submissions

Green Carbon is a Quarterly Scientific Open Access Journal published by KeAi and Elsevier https://www.sciencedirect.com/journal/green-carbon

The editorial office is located at the CAS Qingdao Institute of Bioenergy and Environmental Technology, Qingdao, China. The international advisory board has 55 members, including 23 from Europe.

Since September 2093, it has published 108 articles through 9 issues.

Special issue topics included

Green biomanufacturing
Green chemical catalysis
Green photoelectric catalysis
C1 conversion
Green carbon biomanufacturing

Green Carbon is indexed by CAS, SCOPUS (immediate citescore: 14,9), DOAJ, and under full editorial evaluation for inclusion in the ESCI index.

Until now and probably throughout 2026, Green Carbon operates an APC policy free-of-charge

Beyond a journal, Green Carbon, through its host institute CAS QIBEBT, has developed into an international academic exchange platform, which has hosted recent conferences on Green Carbon, Phototrophic Prokaryotes, Clostridia and more, see http://english.qibebt.cas.cn

For further information, consult with the Green Carbon website https://www.sciencedirect.com/journal/green-carbon or with the Green Carbon Offices in Germany through https://window-to-china.de/green_carbon/

A new Fischer-Tropsch route which eliminates CO2 formation

https://en.people.cn/n3/2025/1031/c90000-20384954.html

https://www.science.org/doi/10.1126/science.aea0774

A group at Peking University has developed technology that almost completely eliminates carbon dioxide by-products during Fischer-Tropsch synthesis (FTS), offering a new route to green syngas conversion and low-carbon chemical manufacturing. FTS converts the syngas of carbon dioxide and hydrogen into liquid fuels or high-value chemicals such as olefins. It serves as the pivotal bridge for turning coal, natural gas, biomass and other carbon resources into fuels and value-added chemicals.

The researchers have used a sodium-modified FeC_x@Fe₃O₄ core-shell catalyst coupling water-gas shift (WGS) with syngas-to-olefins (STO) to convert water into hydrogen in situ. HAE reaches about 66 to 83%, exceeding that of methanol-to-olefins (MTO, 50% upper limit). The approximately 95% carbon monoxide conversion and >75% olefin selectivity were simultaneously obtained. The coupling effect was validated by isotope tracing with deuterium oxide and blocking the WGS pathway, and the contribution of WGS was quantitatively evaluated. These results, using lower hydrogen to carbon monoxide ratios, implied that reducing steam consumption in the WGS reaction and reducing the overall output of carbon dioxide and wastewater enabled a sustainable STO process for potential industrialization.

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