A lipid-rich baker’s yeast mutant provides high yields of palmitoleic acid

http://english.cas.cn/newsroom/research_news/life/202508/t20250801_1048868.shtml

https://biotechnologyforbiofuels.biomedcentral.com/articles/10.1186/s13068-025-02677-8

A team at CAS Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) has  developed a lipid-rich mutant strain of Saccharomyces cerevisiae for microbial production of palmitoleic acid— a rare omega-7 fatty acid with proven anti-inflammatory and metabolic benefits.

The team used a combined mutagenesis approach—employing zeocin, an antibiotic-based mutagen, and Atmospheric and Room Temperature Plasma (ARTP)—to create a diverse library of yeast mutants. They then deployed FlowRACS, a Raman flow cytometry system, to select live yeast cells with elevated lipid levels by analyzing their intrinsic single-cell Raman spectra, eliminating the need for chemical stains or genetic reporters.

This method identified the mutant strain MU2R48, which achieved a lipid content of 40.26%—a 30.85% increase over its parental strain SC018—while maintaining similar biomass production.

Photo: Raman flow cytometry efficiently identifies lipid-rich Saccharomyces cerevisiae  mutants from a Zeocin–ARTP-induced library. (Image by QIBEBT)

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Registration is open: https://conf.sciencemate.com/ICGC2025

ICGC aims to provide an interdisciplinary academic exchange platform and academic community for scientific and technological innovation in the area of CO2 emission reduction and sustainable development. The conference will focus on carbon resources, carbon conversion technologies, carbon life cycle management, and breakthrough developments in green carbon science.

Qingdao Institute of Bioenergy and Bioprocess Technology, CAS/Shandong Energy Institute (QIBEBT/SEI) is a research institute that is active in science and technology developments of bioenergy, fossil energy, hydrogen energy, energy storage devices, and energy informatics, see http://english.qibebt.cas.cn

https://j.people.com.cn/n3/2025/0627/c95952-20333735.html

The tugboat was designed and built by Shandong Port Qingdao Port Group Co., Ltd. and is equipped with a hybrid system of “hydrogen fuel cells + liquid-cooled lithium batteries” to achieve zero carbon dioxide emissions. It can sail for more than 12 hours at a speed of 9 knots and has a towing force of 82 tons. With technologies such as fully automatic smart on-shore charging, it has become the country’s largest port tugboat in terms of horsepower and lithium battery capacity.

https://en.people.cn/n3/2025/0530/c98649-20322033.html

A platform on real-scene 3D modeling of the city of Qingdao was launched in March 2021 under the leadership of the Qingdao Institute of Survey and Mapping

Qingdao’s varied topography – marked by hilly terrain and dramatic elevation changes – necessitated the use of oblique aerial imaging to capture raw imagery and build an accurate 3D model. The project team deployed manned fixed-wing aircraft equipped with 150-megapixel, five-lens oblique aerial cameras. The aerial survey covered the entire urban area, achieving a ground resolution of 15 centimeters and maintaining more than 70 percent image overlap to maximize accuracy.

In March 2022, following expert review, the project was officially launched for citywide application. Today, the platform covers Qingdao’s entire land area – 11,000 square kilometers – as well as 800 kilometers of coastline, 49 bays, and seven inhabited islands.

The 3D simulation platform has been shared with over 60 municipal departments. It supports more than 100 key functions, including disaster prevention and mitigation, urban planning, social governance, and urban renewal. The platform also underpins over 70 digital government service applications and records nearly 100 million uses annually. As an example, at the bureau’s headquarters, staff members examined two versions of a digital model for a former mining site in Qingdao’s West Coast New Area. The comparison revealed tangible signs of ecological restoration – more vegetation and a gentler slope. Qingdao is home to 898 legacy mine sites. In the past, inspecting these sites required a full month of on-the-ground efforts. Now, with the help of the 3D model, the same work takes just five days.

Since 2023, the city has carried out annual temporal updates to the city-scale 3D simulation platform, enabling it to track urban changes with precision and support data-driven lysis and evidence-based planning.

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