https://www.pnas.org/doi/10.1073/pnas.2515324122

http://english.cas.cn/newsroom/research_news/chem/202511/t20251117_1115869.shtml

A team led by Prof. ZHOU Yongjin from the CAS Dalian Institute of Chemical Physics has combined lifespan engineering strategies with metabolic pathway optimization in Saccharomyces cerevisiae, thereby enabling highly efficient sclareol biosynthesis. Using high-producing sclareol strain, they found that simultaneously weakening nutrient sensing and enhancing mitophagy, together with metabolic pathway optimization, resulted in a sclareol production of 25.9 g/L.

Omics analysis showed that weakening nutrient sensing and enhancing mitophagy enhanced central metabolism and cellular robustness by extending chronological lifespan and regulating metabolic gene expression, thereby improving product synthesis in Saccharomyces cerevisiae during the later stages of cell growth.