https://english.news.cn/20250417/e7d7f7cf15844397ba6917535f8c3346/c.html
https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202415417?af=R
Researchers at Lanzhou University Hospital have designed a magnetoelectric bionic cartilage hydrogel incorporating piezoelectric poly(3-hydroxybutyric acid-3-hydroxyvaleric acid) (PHBV) and magnetostrictive triiron tetraoxide nanoparticles (Fe3O4 NPs) into sodium alginate (SA) hydrogel. The dual-network, semi-crosslinked chain entanglement structure features similar composition, structure, and mechanical properties to natural cartilage. After the implantation of cartilage, the motion-driven magnetoelectric-coupled cyclic transformation model triggered by gentle joint forces initiates a piezoelectric response that leads to magnetoelectric-coupled cyclic transformation. The hydrogel induces defective cartilage repair superior to piezoelectric or magnetic stimulation alone.
