https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(25)00005-0

https://www.cas.cn/cm/202501/t20250130_5046412.shtml

Researchers from the CAS Institute of Zoology and from Sun Yat-sen University through embryonic stem cell engineering technology have successfully bred mice from two mouse fathers. The “parthenogenenetic” mice lived to adulthood.

The researchers constructed haploid embryonic stem cells with 20 gene-edited imprinted regions (without the mother’s genetic information), and injected them into enucleated oocytes together with sperm, successfully transforming them into viable fetuses and fully functional placentas.

According to the researchers, the parthenogenetic mice constructed this way are significantly different from ordinary mice. Their weight grows rapidly. When the weight of ordinary mice reaches 20 grams, the weight of parthenogenetic mice is about 30 grams. Parthenogenetic mice also show a stronger desire to explore, frequently entering the central area in the open field experiment, which is very different from the habit of rodents to move along the edge.