https://www.cas.cn/syky/202401/t20240130_5002061.shtml
https://pubs.acs.org/doi/10.1021/jacs.3c12815
Lipoarabinomannan (LAM) from the Mycobacterium tuberculosis cell envelope represents important targets for the development of new therapeutic agents against tuberculosis. Researchers from the CAS Kunming Institute of Botany have developed a modular and efficient synthesis of Mycobacterium tuberculosis mannan cap lipoarabinomannan 101 sugar through a one-pot glycosidylation reaction and have achieved chemical synthesis of lipoarabinomannans with >100 monosaccharides and can serve for the development of chemotherapeutic drugs.
Chemical synthesis of tubercle bacillus cell wall components will help to develop drugs