A joint research group composed of JING Xiaoyan, GONG Yanhai and XU Teng, have developed a RAGE-Seq technology, starting from liquid-phase Raman analysis of D2O-fed soil flora, isolating and wrapping bacterial single cells with specific Raman phenotypes into skin-up droplets, and then doing downstream genome sequencing. By this method, they could cover individual single cell genomes by over 90% and elucidate individual carotenoid synthesis pathways.

CAS news release, June 9, 2021