ZHAO Qilong from the CAS Shenzhen Institute of Advanced Technology (SIAT) and WANG Min from the University of Hong Kong have developed a new method for biomanufacturing of vascularized tissue. They have encapsulated endothelial cells  in hydrogel microspheres and deposited them  along with vascular endothelial growth factor (VEGF)-containing nanofibers in the scaffold fabrication process, resulting in nanofibrous scaffolds with 3D embedded cell-encapsulated microspheres. After selective disruption of the hydrogel microspheres, the encapsulated endothelial cells were released, yielding bioactive nanofibrous scaffolds with tissue-like 3D cell-incorporated nanofibrous structures which could freely stretch, display enhanced intercellular connections, and maintain the phenotype in the bioactive nanofibrous scaffolds, indicating improved vascularization potential. 

CAS news release, February 3, 2021