The enzyme which is important for the synthesis of various drugs (APIs) has been derived from Chryseobacterium sp. CA49 and, by protein design, been improved to stand 65 C for 15 d at > 95 % residual activity as compared to the wild type enzyme which has a half-live of only 12 min under these conditions.
CAS news release, March 2, 2016
CAS Institute of Biology obtains carbonyl reductase with high thermal stability