http://english.cas.cn/newsroom/research_news/life/202508/t20250804_1048985.shtml
Researchers at the CAS Institute of Genetics and Developmental Biology have developed a programmable, chromosome-level, precise manipulation technology for large DNA fragments, called PCE, by integrating three innovative, systematic technical approaches. In experiments with animal and plant cells, this technology demonstrated powerful capabilities, successfully achieving complex operations such as the precise insertion of large DNA fragments containing 18,800 base pairs, the targeted replacement of DNA sequences containing 5,000 base pairs, the inversion of long chromosome segments containing 12 million base pairs, the deletion of long chromosome segments containing 4 million base pairs, and even the movement of entire chromosomes.
