https://www.cas.cn/cm/202507/t20250728_5077933.shtml

Researchers at the CAS Shenzhen Institute of Advanced Technology and the Burn Plastic Surgery Department of Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine have developed a new hemostatic dressing T-BC based on biocellulose.

Commonly used hemostatic agents generally have problems such as easy rebleeding during dressing changes, poor adhesion and insufficient mechanical strength. In response to these pain points, the research team used synthetic biology technology to combine recombinant human thrombin through specific cellulose and structural domains, and anchored it on a biocellulose matrix to construct an integrated dressing T-BC with both hemostasis and healing functions. The dressing achieves multi-faceted regulation of the wound repair process at the molecular level through the triple synergistic effects of promoting new blood vessel formation, regulating inflammatory response, and reconstructing skin tissue structure, thereby significantly accelerating the healing process.

In a rat liver incision model, the dressing achieved rapid hemostasis within 1 minute. In a rat experiment simulating deep second-degree burn wounds, the experimental group treated with T-BC had a wound healing rate that was about 40% higher than that of the control group after 5 days.

In addition, the study used biomolecular self-assembly technology, which only required soaking in a mild protein solution to achieve efficient fixation of thrombin. This innovative method not only completely retains the biological activity of thrombin, but also has significant environmental advantages.

The research team also conducted a comprehensive biosafety assessment of T-BC, including cytotoxicity experiments, hemolysis experiments, and tissue compatibility tests. The experimental results all confirmed that T-BC has good biosafety, which provides reliable guarantee for its clinical application.