https://www.nature.com/articles/s41378-024-00837-8

http://en.people.cn/n3/2025/0228/c90000-20283115.html

Researchers from the CAS Shenzhen Institutes of Advanced Technology have developed an efficient and power-free whole blood separation device based on the principle of negative magnetophoresis. Under the action of an external magnetic field, the diamagnetic particles and paramagnetic medium will generate negative magnetophoretic force due to different magnetic susceptibility, pushing the diamagnetic particles or cells to the minimum of the non-uniform magnetic field.

The new device can adjust the processing volume per cycle from 100 microliters to 3 milliliters. It can separate 3 milliliters of whole blood in as fast as 1 minute, with a separation efficiency as high as 99.9 percent.

The researchers carried out rats and human whole blood separation, as well as subsequent plasma biomarker detection tests to validate the device’s separation performance and broad applicability.