https://www.cell.com/cell/abstract/S0092-8674(24)01375-8

http://en.people.cn/n3/2024/1225/c90000-20258482.html

A research team led by Yang Qing from the Agricultural Genomics Institute at Shenzhen under CAAS  has discovered a unique type of ABCH transporter responsible for transporting lipids to the insect cuticle, contributing to the formation of the insect’s lipid barrier. This protein is also linked to pesticide resistance in pests. The ABCH protein is present in all insects and other arthropods, but absent in humans and other mammals and plants, making it an ideal molecular target for creating pesticides, according to the researchers.

The study uncovered a unique interaction mechanism between the ABCH transporter, lipid molecules and insecticide molecules. The researchers also obtained a small molecule inhibitor that can restrain the transport function of ABCH and identified effective ingredients that can be directly used in the synthesis of green pesticides.

This research is hoped to be a significant breakthrough in the fields of entomology and pesticide target studies, laying a crucial foundation for the development of green pesticides.