https://www.nature.com/articles/s41586-024-08280-5

The aim of the π-HuB project is to (1) generate and harness multimodality proteomic datasets to enhance our understanding of human biology; (2) facilitate disease risk assessment and diagnosis; (3) uncover new drug targets; (4) optimize appropriate therapeutic strategies; and (5) enable intelligent healthcare, thereby ushering in a new era of proteomics-driven phronesis medicine.

The plan, a global big science initiative led by Chinese scientists around Fuchu HE, is expected to last for 30 years, and the three core goals in the first 10 years include building a human proteome map, developing a “meta-smart human” large-scale language model, and building a computationally-driven “navigation system” for the state of the human body. It is currently supported by 114 top-level scientist teams from more than 20 countries and regions. The participation of multinational and multi-institutional organizations with complementary advantages has formed a global collaborative research network.