Macaque survives over 180 days after pig kidney transplant

http://en.people.cn/n3/2024/1202/c90000-20248927.html

On May 10, researchers at an affiliated hospital of Tongji Medical College under the Huazhong University of Science and Technology had transplanted a single genetically edited pig kidney into a macaque, replacing its native kidneys. Utilizing an enhanced immunosuppression protocol, the transplanted kidney functioned successfully for 184 days.

In animal studies involving grafting organs between different species, survival of 180 days is deemed a benchmark for long-term survival. Often, in the first five months after the transplant, the grafted kidney functions well and has normal physiological readings. Chronic rejection sets in after that point. To initiate clinical studies on humans, achieving long-term survival in animal trials is a prerequisite,

In March, Harvard Medical School physician-scientists transplanted genetically modified pig kidney into a human with kidney failure. The 62-year-old man died two months later.

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