A record high! 15 Qingdao achievements won National Science and Technology Awards

http://qdstc.qingdao.gov.cn/kjdt/bskjdt/202407/t20240702_8109856.shtml

The 2023 National Science and Technology Awards were announced in Beijing. From a total of 262 projects and candidates,15 achievements in Qingdao won the National Science and Technology Award

Qingdao hosted and completed 2 award-winning projects, participated in the completion of 13 award-winning projects – Including 1 special prize, 1 first prize, 11 second prizes.

5 of the award-winning Qingdao projects are in the maritime field, namely:

“Key Technology Equipment and Application of Deep Sea Image Detection”
Offshore Petroleum Engineering (Qingdao) Co., Ltd. participated in and completed the “‘Shenhai No. 1’ ultra-deepwater gas field development project key technology and application” project, which won the first prize of the National Science and Technology Progress Award
“Construction and Industrial Application of Precision Nutrition Technology System for Marine Cultured Fishes” led by the Ocean University of China and participated by the Yellow Sea Fisheries Research Institute of the Chinese Academy of Fishery Sciences.
“Theoretical and Technological Innovation and Major Discovery of Deep Oil and Gas Exploration in Fault Zones” project, and the
“Key Technologies and Applications for Beach Protection and Restoration of Complex Coastal Environments” participated by Ocean University of China won the second prize of the National Science and Technology Progress Award.

In addition, Qingdao’s participation in award-winning projects has high “gold content” and broad influence. Among them, the “Fuxing High-Speed Train” project completed by CRRC Qingdao Sifang Rolling Stock Co., Ltd. and CRRC Qingdao Sifang Rolling Stock Research Institute Co., Ltd. won the special prize of the National Science and Technology Progress Award. The “Fuxing” high-speed train is a new generation of high-speed train independently developed by China and with complete intellectual property rights. With a maximum speed of 350 kilometers per hour, China has become the country with the fastest commercial operation of high-speed rail in the world. This record remains to this day. As of the beginning of this year, the “Fuxing” high-speed train has transported more than 2.2 billion passengers.

Enterprise innovation is the fundamental driving force and internal source of innovation. Among the Qingdao award-winners, 9 projects have enterprises taking the lead in completing and deeply participating in them. For example, the “Technological Innovation and Industrialization of Temperature and Humidity Oxygen Magnetic Multi-dimensional Precision Control of Household Preservation Appliances” project led by Haier Smart Home Co., Ltd. and participated by Qingdao Haier Refrigerator Co., Ltd. won the second prize of the National Science and Technology Progress Award; Tsingtao Brewery Co., Ltd. The project “Efficient Breeding and Optimization of Key Technologies and Applications of Food Biomanufacturing Industrial Strain”, as the main completion unit, won the second prize of the National Science and Technology Progress Award.

more insights

An automated digital colony picker monitors growth and metabolite production, eliminating the need for culturing cells

https://www.nature.com/articles/s41467-025-63929-7

http://english.cas.cn/newsroom/research_news/life/202510/t20251014_1089412.shtml

The group around Jian XU from the CAS Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) has developed a fully automated “Digital Colony Picker” (DCP). This device identifies and retrieves high-performance microbial clones by simultaneously monitoring their growth and metabolite production—eliminating the need for culture plates, sampling needles, or manual picking.

Designed for the “design-build-test-learn” framework widely adopted in synthetic biology, the DCP streamlines the traditionally slow, labor-intensive “test” phase into a fast, parallel workflow with little hands-on time. It has a microfluidic chip containing 16,000 addressable microchambers that isolate single cells and track their expansion into micro-colonies. An integrated AI engine conducts time-lapse analysis of both brightfield and biosensor signals to quantify growth kinetics and metabolite production in real time. Once target colonies are identified, a laser-induced bubble technique exports them as droplets directly into standard culture plates. This contact-free transfer minimizes cross-contamination and preserves cell viability.

The equipment which was tested for identifying high-yield or lactate-tolerant Zymomonas mobilis mutants is broadly applicable to adaptive evolution studies, functional gene discovery, and phenotype screening across diverse microbial species.

Epigenetic modifications help algae to adapt to low CO2 environments

http://english.cas.cn/newsroom/research_news/life/202510/t20251010_1089023.shtml

https://www.cell.com/plant-communications/pdf/S2590-3462(25)00296-2.pdf?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2590346225002962%3Fshowall%3Dtrue

A research team from the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) of the Chinese Academy of Sciences has identified a specific histone modification as the key regulator governing microalgae’s adaptation to low-CO₂environments.

The study focused on Nannochloropsis oceanica, tracking its epigenomic dynamics as it transitioned from an environment with 5% CO₂ to one with just 0.01% CO₂. Using multi-dimensional epigenomic sequencing techniques, the researchers discovered that global DNA methylation in the alga remained stable at 0.13%, effectively ruling out DNA methylation as a major driver of its low-CO₂response. By contrast, H3K4me2 methylationwas found to be closely associated with 43.1% of the genes that respond to low-CO₂ conditions. These genes include those critical to photosynthesis and ribosome biogenesis, two processes essential for the alga’s survival under carbon-limited stress. Further analysis revealed that H3K4me2 appears to regulate gene transcription by altering chromatin accessibility, a mechanism that aligns with its role as a central regulator of low-CO₂ adaptation.

To validate their findings, the team used CRISPR/Cas9 gene-editing technology. They knocked out NO24G02310—a gene that encodes an H3K4 methyltransferase, the enzyme responsible for adding methyl groups to H3K4. The modified algae showed a roughly 22% reduction in growth rate and a 15% decrease in biomass. Additionally, the levels of another histone modification (H3K4me1) dropped, and the genome-wide localization of H3K4me2 shifted—providing direct evidence of H3K4me2’s role in low-CO₂ adaptation. Further experiments uncovered that H3K4 modification may act via two pathways: by regulating enzyme networks and by modulating chloroplast transmembrane pH gradients. Both mechanisms work to optimize the alga’s use of available CO₂, enhancing its survival under low-carbon conditions.

Sorting cells by Raman fingerprint

Nachrichten aus der Chemie (2025) 73, p. 37 – 39 (in English)

Raman article

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