https://www.nature.com/articles/s41538-024-00307-5
http://en.people.cn/n3/2024/0910/c90000-20217329.html
A study conducted by Professor Li Xiangkai at the School of Life Sciences at Lanzhou University has revealed that the probiotic Limosilactobacillus fermentum GR-3, derived from “Jiangshui,” a traditional fermented food in northwestern China, demonstrates potential for promoting apoptosis in colon tumor cells and inhibiting their proliferation. GR-3 exhibited superior antioxidant capacity by producing indole derivatives ICA and IPA. In an AOM/DSS-induced CRC mouse model, GR-3 treatment alleviated weight loss, colon shortening, rectal bleeding and intestinal barrier disruption by reducing oxidative stress and inflammation.
Colorectal cancer is one of the most common cancers in China. While existing research primarily focuses on how probiotics regulate the host immune system, there has been comparatively little exploration of their antioxidant properties and ability to modulate gut microbiota.