A research team, led by Jun-An Chen, Ph.D. from Academia Sinica Taiwan in Taipei, sequenced 10,000 motor neurone (MNs) in the spinal cord of mouse embryos at the single-cell level. The team discovered new subtypes within known MN types and reported their genetic markers. They also compared subtype diversity among different species.
The single-cell-level cell atlas of spinal cord MNs provided by this study will be a valuable resource for neuroscience research and will help unravel the mysteries surrounding the vulnerability of MNs to neurodegenerative diseases such as spinal muscular atrophy and amyotrophic lateral sclerosis. The research is also expected to help solve the mystery of MN vulnerability to neurodegenerative diseases such as spinal muscular atrophy and amyotrophic lateral sclerosis.