Caloric restriction inhibits tumor growth in mice through enrichment of bifido bacteria

https://www.nature.com/articles/s42255-022-00716-4

Scientists from Fudan University found in rodent experiments that after caloric restriction, Bacterium bifidum is enriched. Then the tumor growth is significantly inhibited. The administration of these bacteria is sufficient to achieve antitumor effects in microbiota-depleted mice. The study shows that B. bifidum mediates caloric restriction-induced antitumor effect through acetate production and also depends on the accumulation of immune cells in the tumor microenvironment.