Base Editors can modify specific bases in the genome, offering hope for correcting false single nucleotide variations (SNVs) in humans. Researchers around Wang Meng at the CAS Tianjin Institute of Industrial Biotechnology have developed an automated high-throughput gene manipulation platform for mammalian cells which can automate the editing of thousands of animal cell samples within one week. Based on the large in situ genome editing data obtained by the automatic high-throughput platform, the researchers developed an AI-based platform which accurately predicts the result of in situ base editing. This work is expected to accelerate the development of base-editor-based genetic therapies.
CAS Tianjin Institute of Industrial Biotechnology proposes system for base editing in mammalian cells