The groups of YAO Yong-Gan, DI Ying-Tong and HAO Xiao-Jiang in Kunming, Yunnan Province, after isolating harpertrioate A, a C-30 limonoid, from branches of Harrisonia perforate in Hainan, have found in experiments with U251-APP cell cultures that this compound exhibited biological activities against Alzheimer’s disease by reducing Aβ42 and Aβ40 production and shifting APP processing toward the nonamyloidogenic pathway. The effect of the compound on the Aβ production was comparable to that of gemfibrozil.
Xiao-Han Tang et al., Org. Lett. 2021, 23, 2, 262–267; https://doi.org/10.1021/acs.orglett.0c03460