A team around ZHANG Yan has developed a cell surface immobilization technology to enhance the therapeutic effect of adopted immune T cells on real tumors. They have discovered that avasimib raises cholesterol levels in cell membranes and promotes speedy aggregation of T cell receptors by mimicking the properties of transmembrane proteins and hydrophobic effects. As a result, T cell vitality and therapeutic effects of T cells on real tumors are enhanced. In mice, the remodeled T cells showed therapeutic effects on three types of body tumors: non-invasive melanoma, melanoma lung metastasis, and non-invasive glioblastoma.
Japan JST China news, January 4, 2021
Team at China Pharmaceutical University improve T-cell therapy by lipid membrane modulation: animal experiments