Team around CAS SIBS creates functional yeast cell with single chromosome

In a cooperative effort of teams from CAS SIBS and the Academy of Military Medical Sciences in Shanghai and the Wuhan Feisha Gene Information Co., a functional single-chromosome yeast was evolved from a Saccharomyces cerevisiae haploid cell containing sixteen linear chromosomes by successive end-to-end chromosome fusions and centromere deletions. The single-chromosome artificial cells had nearly identical transcriptome and similar phenotypical profiles as wild-type yeast,  but exhibited reduced growth and showed some other deficits (article in Nature). The team will further use this organism to study differences between single-chromosome prokaryotic and eukaryotic microorganisms. The present achievement is hailed as a major contribution of scientists in Shanghai to synthetic biology, after the chemical synthesis of bovine insulin and tRNA in the 1960ies

CAS news release, August 2, 2018

Team around CAS SIBS creates functional yeast cell with single chromosome
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