The group of Zhaobing GAO has found that a channel protein in the neuron cell membrane, TRPA1, mediates organophosphate-induced neuropathy and that TRPA1 can be targeted effectively with existing drugs such as duloxetine and ketotifen (screened from over 2000 approved drugs) to alleviate effects. TRPA1 is a channel protein that mediates the movement of calcium ions into neurons, an important part of the process that leads to activation of a neuron and physiological effects such as smell, taste, vision and temperature sensation.
CAS news release, August 2, 2017
Team at CAS Shanghai Institute of Materia Medica identifies antidots for organophosphate poisoning