Lincosamides are clinically important glycoside antibiotics for the treatment of infections from Gram-positive pathogens. The group of Wen LIU has clarified the mechanism by which lincomycin A can be transformed into a number of active derivatives which, by the use of synthetic biology, might lead to improved manufacturing processes.
CAS news release, August 26, 2016
CAS Shanghai Institute of Organic Chemistry elucidates biosynthetic pathway of lincosamide antibiotics