Resveratrol, a compound found in red wine, reduces the risk of heart disease. Researchers around MI Mantian have found in mice that resveratrol can remodel the gut microbiota including increasing the Bacteroidetes-to-Firmicutes ratios, significantly inhibiting the growth of Prevotella, and increasing the relative abundance of Bacteroides, Lactobacillus, Bifidobacterium, and Akkermansia. The changed intestinal flora reduced levels of trimethylamine-N-oxide (TMAO), a known contributor to the development of atherosclerosis, by inhibiting production of trimethylamine, its precursor.

CAS news release, April 7, 2016