Group at Shanghai Institute of Organic Chemistry finds softer route to steroidal sapogenins

The team of Weisheng TIAN developed a process in the pilot scale which allows to oxidize sisal saponin to megestrol acetate using hydrogen peroxide instead of chrome oxide. China produces 4.000 t/a of saponins, about 90 % of the global production. The method was used to manufacture pregn-16-ene-20-one-3-ol acetate and other steroid drugs. Industrieller Partner ist Jiangsu Jiaerke Pharmaceuticals Co. in Changzhou.

China Bio news release, Jan. 28, 2015

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