In collaboration with CAS Institute of Genetics and Developmental Biology, researchers around Liangxue LAI developed Tibet mini-pig mutants which will develop amyotrophic lateral sclerosis (ALS) within a few months. To this end, a mutant human SOD1 gene was expressed using somatic cell nuclear transfer. The pigs will be used to study the mechanism and therapy of this disease.
Huaqiang YANG et al., Cell Research 2014, doi 10.1038/cr.2014.25
CAS Guangzhou Institutes of Biomedicine and Health develop ALS mini-pigs