Artificial fusion proteins enhance methanol bioconversion
Methanol produced from coal is a key raw material in coal-rich China. A team around SUN Jibing at CAS Tianjin Institute of Industrial Biotechnology constructed fusion proteins of ribulose monophosphate pathway enzymes. The fusion engineering strategy enhanced methanol bioconversion to fructose 6-phosphate (F6P), an important metabolic intermediate. NAD-dependent methanol dehydrogenase (Mdh), 3-hexulose-6-phosphate synthase (Hps) and 6-phospho-3-hexuloisomerase […]